é¦?é¡?/a>> ä¸?å­?ä¸???/a>> ä¸?å­?ä¸???/a>> å¤????µå·¢> å¤????µå·¢çºµé??å­?å®??ä¼???å­???

ç²¾é????ç­?(1)

??äº???/span>??¸»ä»»å?»å??¿æ?å¸?å¦?å¹¼ä??¥é??/span>ä¸???/span>

???¿ï?ä¸?å­?ä¸??²ä???æ®?????æ³??¾ç??

????/p>

å¤????µå·¢çºµé??å­?å®?????è¿?æ²»ç????å­? ??å¤????µå·¢ç»¼å???????ç§?????æ³?失è?导è?´ç???¾ç??ï¼???纵é??å­?å®????ç§???天æ?§å???²å?常ã??è¿?两ç????µé?½å???½å½±??女æ?§ç?????²è?½å?????¶è??ï¼???è¿????©æ²»??????æ´»æ?¹å???è°??´ï?å¤????µå·¢ç»¼å??????»¥å¾??°æ?§å?¶ï???纵é??å­?å®???»¥??è¿?????²»??????æ­¤ï?å¦???å¾??°é??å½???æ²»ç??ï¼?女æ?§ä??¶æ?????½æ??å­???

2022-04-13 17:16

举æ??/a>

???ȍ??????/p>

?¾ç???¾ç?

?¾ç???¾ç?

??/i>å¤????µå·¢

å¤????µå·¢ç»¼å??å¾????ç§??µå·¢å¢?大并????å¾?å¤???满液ä½???å°???ï¼???æ¿?ç´?æ°´å¹³å¢?é«???ä¸??½æ???µç??????æ³??¾ç???????¾è?????¹å????????µã??

  • ???¶èµ·??ï¼?ä¸?????ä¼?å­þ@??ç´? PCOS???ç§?常æ???²ä??¾æ?§é??ä¼?ï¼???Xä¸?è¿???(ä¼´æ????ä¼?ï¼????ºå??çª?????å¼?èµ·ç???¾ç????å¤??°æ?£è?????²ä??¸å??46ï¼?XXï¼??¨å???£è???????²ä??¸å????åµ?????å¦?46ï¼?XX/45ï¼?XO;46ï¼?XX/46ï¼?XXq??46ï¼?XXq?? äº????¾ä??ºè???¨å??è¯ Chom(1973)认为ï¼?PCOSèµ·æ?äº????¥å???¾ä??ºç?¾ç??ï¼??³å????°å¼º??åº?æ¿??ºæ??¶ç??¶å¸¦??æ³?è¿?å¤???æ¿?ç´?ï¼?并å?¨æ?§è?ºå?è½???为é???????é¦??§å?°å?èµ?Pè½?nRH-GnH???¾è??å¾?ç´?ä¹±ï?LH/FSHæ¯??¼å??é«?ï¼?继å??å¼?èµ·å?µå·¢??æ¿?ç´?????å¢?å¤?ï¼??³è?¾ä??ºå???µå·¢?±å????æ³?è¾?å¤???æ¿?ç´??´æ??é«???æ¿?ç´?è¡?????é«???æ¿?ç´?è¡????¨å?µå·¢??å¼?èµ·è???纤维??å¢????????¶å?µæ³¡???²å???µï??????µå·¢???§å?大å???¢æ?§æ?????µã?? 1??????????????PCOS??????å°?ä¸?æ¸?æ¥???ä¸????为ä?ä¸?ä¸???-??ä½?-?µå·¢è½´å???½å¤±å¸¸ã???¾ä??ºå???½ç?ä¹±ã????ä¼???代谢ç­???ç´????³ã??å°???COS?£è?????§æ???²ä???常æ???²ä?å¼?常ï???äº?è¿???家æ???²ã??è¿??¥å???°æ??äº??ºå??(å¦?CYP11A???°å?ç´??ºå????VNTR)ä¸?PCOS???????³ï?è¿?ä¸?æ­¥è???äº???ä¼???ç´???COS????ä¸???ä½??¨ã?? 2???????ºå?¶ã????PCOS???????ºå?¶å???ï¼?å·²è??????äº?å®??????é«?LHä¼´æ?常æ??ä½?æ°´å¹³??FSH;?¡é??æ¿?ç´?å¢?å¤?;?¢æ??å®?????æ¿?ç´?æ°´å¹³(E1æ¯?E2é«?);?£è?°å?ç´??µæ??(é«??°å?ç´?è¡???);?¤å?µå·¢ç»?ç»?å½¢æ??å­þ????å¤?ä¸????§å?µæ³¡???´è´¨å¢????? 1ï¼?ä¿??§è?ºæ?ç´????¾å?å¸ PCOS?£è????è¡?LH??é«?ï¼???FSH正常????ä½?ï¼?LH/FSH¡Ý2ï½?3ï¼?????注å?GnRH??LH???ºç?°è?åºþ@??åº?ï¼?认为???½å????äº?ä¸?ä¸???-??ä½????½å¤±è°????¨ä?ä¸???ä¸??å·´è?ºè?½å???¿ç???½è?½ç?ç»?å¯?nRHç¥?ç»????????¶ä??¨å¤±?§ï??????H??æ³?å¢?????ä½??´å???½æ????æ¿?ç´?????é¦????¶å?常æ???´ã?????¨æ???§ç???ºå?è½??????¥ç????æ¿?ç´?(????1)å°?导è?´å?LH??æ³???æ­£å??é¦???å¯?SH??æ³???è´???é¦????¶ã??LH?ºæ??µæ³¡ç»???å¢???ï¼?产ç??大é????æ¿?ç´?ï¼???æ¿?ç´?ä¸??½å?¨é?¨è½¬??????æ¿?ç´?ï¼?è¿?ä¸?æ­¥å????ºå??³é???E1????????è¿?å¤???æ¿?ç´?使å?µæ³¡???????µå·¢????纤维????????å¢??????±ä?缺ä???ç»??¨æ??ä¸?????LHå³°å?¼ï??ºç?°æ???µé??ç¢?(??)??æ­¤å?ï¼???人å????COS?£è?????µå·¢ä¹????½å??æ³??????¶ç?¡±ï¼?????SH????æ³?ï¼?å½±å???µæ³¡?????²æ????ï¼??ºç?°è?å¤????¶å?µæ³¡ï¼?è¿?å¹´å???°é??°å?ç´?è¡?????å¢?é«???IGFä¹???½¿LH??æ³?å¢?å¤??? 2ï¼???æ¿?ç´?è¿?å¤? ??COSä¸????ä¹?????????æ¿?ç´???????å¢?å¤??????§æ?ç´?ç»?????????SHBG)??å°?ï¼?游ç???æ¿?ç´?å¢?å¤?ï¼?æ´»æ?§å?强ã???³ä?è¿?å¤?????æ¿?ç´??¥æ?äº??µå·¢???¾ä??ºä?说ä?ä¸???大å????GnRHæ¿??¨å??????ä½?ä¿??§è?ºæ?ç´?ï¼???????????¾é????å°?ï¼???对æ?¥æ?äº??¾ä??ºç??DHEAS??å½±å???????¥é??大约70%??PCOS?£è??为å?µå·¢æº??§é??æ¿?ç´????´ï????±ä?ç±»å?ºé??æ¿?ç´??????¶ç³»???½ç?ä¹±ï?å¦??³é????¶ç¼ºä¹?ï¼?3¦Â-???¾è?±æ°¢?¶ä?足æ??æ´»æ?§ä???ï¼?P45OC17Aè°???å¼?常ï???æ¿?ç´???????ç¢?ï¼?大é????æ¿?ç´??¨å??????????????¾å??)è½???¸º??????ä¹???人è?为å?µå·¢???²ä?????使è?³é????¶ç??æ´»æ?§ä???????H???²é??????????é«?ï¼??ºæ??µæ³¡??ç»??????´è´¨ç»???å¢???????æ¿?ç´?????????è¿?å¤?????æ¿?ç´?ä¿?使å?µæ³¡????ï¼??µå·¢ç²?å±?ç»????©æ??é»?ç´???ï¼????¿å??æ­??ä¸??½æ???µï?å½¢æ??PCOS?? ????å¤??????¨é???¥æ????ç»???æ½???ï¼??¨æ????½èµ·??äº??§æ????????ï¼??¾ä??ºå???½å¤±è°?ï¼???ç»???æ³?è¿?å¤???æ¿?ç´???æ­¤å?ï¼??¨å??¨å?°å?ç±³æ?¾å????æµ?å®??µå·¢???¾ä??ºé????è¡?ä¸?????ç§???æ¿?ç´?æ°´å¹³ï¼??¶ç????????µå·¢???¾ä??ºæ??COSè¿?å¤???æ¿?ç´????±å???¥æ?ï¼?????0%PCOS?£è?????¾ä??ºæ??§é??æ¿?ç´?å¢?å¤??? 3ï¼??????å¤? PCOSå¦?女ç?¨å???????©æ???¤é???§å?å®??ºè?ï¼???æ°?????ºå????´å?µæ³¡???????µï???ç»??¥æ½®ï¼?è¿???ç¤?COS?£è??ä¸?ä½???æ¿?ç´?æ°´å¹³é«?ï¼???ä¸???æ¿?ç´?ä¹?å¢?å¤???ä½???æ´»æ?§é??æ¿?ç´???????äº???(E2)??????E1)ï¼?E2主è??¥æ?äº??µå·¢ï¼?E1???¥è???µå·¢???¾ä??ºå???¨å?´ç?ç»???è½?? ¬??PCOS?£è?????¨æ????1???¾å?å¤?ï¼?E1/F2æ¯???å¢?é«?(正常E1/F2??)ï¼??¹å?????¥è???????????ï¼??³é????¶æ´»?§é?ï¼?å¤??¨ç?ç»?è½??¢å?å¤?ï¼?E1æ°´å¹³???´é?ï¼???ä¸??¥æ?äº?å¤??¨ç?ç»???E1ä¸?????ä½?ä¿??§è?ºæ?ç´???è°???ï¼????¨æ???§å????????ç»??æ°´å¹³????æ¿?ç´?对ä?ä¸???-??ä½?????é¦?è°??????正常???? 4ï¼?ç»????²ç?P450C17Aè°???失常 PCOS主è?缺é?·æ???ä¸???-??ä½??¥å??å¼?常ç????é¦?ä¿¡å?·ã??è¿????½ä??µå·¢???¾ä??ºæ??º«??????æ³???????æ³?è°????ºå?¶é??ç¢????³ã??PCOS?£è??常伴17-ç¾?å­???17-OHP)??é«?ï¼?è¿????±ä??µæ³¡??ç»????????¾ä??ºç??¶å¸¦??P450C17A??è°????ºå?¶å¤±å¸¸æ???´ã??P450C17A?·æ??17-ç¾????¶å??17ï¼?20-?¾è??¶ç??????æ´»æ?§ï??¨â??å°?å­???½¬??¸º17-OHP???????????¨â??å°?å­??????????ä¸?7-ç¾?å­?????????DHEA??????17-ç¾?å­????¢æ???¾ä??ºå??????´¨??????è¦???ä½??©è´¨.ä¹????µå·¢?????§æ?ç´??¹å??????æ¿?ç´?????è¦???ä½????¥ç?äº?PCOS?£è??GnRH-A??HCG(?¹å???¨ç?¨å?°å?ç±³æ?¾æ???¶å??)ï¼?17-ç¾?å­???????????????¾å??é«?;??ACTH?´å?è¯?éª????½ä?使è?¾ä??ºç??DHEAä¸?17-OHP???¶å?å¤?ï¼???示å?µå·¢???¾ä??ºç??¶å¸¦??P450C17Aæ´»æ?§å?é«?????æ­¤ï?P450C17Aæ´»æ?§è???å¼?常æ???¾ä??ºå???µå·¢??æ¿?ç´?è¿?????æ³?????è¦???????ä½?为ä?ä¹?ä¼??ºç?°ç±»?ºé????????è°???å¼?常å?ä¸?æ¸?æ¥????°å?ç´?/IGFsç³»ç????ºæ??µå·¢???¾ä???450C17A mRNA表达???¶æ´»?§ã??æ­¤å?ï¼?CYP11A??侧é?¾è?解é?¶å?ºå??ç¼????ºä?产ç??è¿?å¤???æ¿?ç´????³ã?? 5ï¼??°å?ç´??µæ??ä¸?é«??°å?ç´?è¡??? PCOS?£è??ä¸?论æ?????¥è??ï¼?å¤???ä¸???ç¨?åºþ>???°å?ç´??µæ??ä¸?é«??°å?ç´?è¡?????è¿??????°å¤§çºþ=??????COS?£è????????ä¸??°å?ç´???ä½?ä¸?æ°¨é?¸ç£·?¸å??缺é?·æ???³ã??????认为?°å?ç´??¨å?¶å????ä¸???????è¦??°ä????°å?ç´?ä¸?IGF-1??è¿?IGF-1??ä½?ä½??¨ä??µæ³¡??ç»???ï¼?ä¿?使é??????????¾é????????è¿?å¹´ç????究å???°ï???ä½??»è??¨ä????°å?ç´???ä½?ï¼????????¶å??¨ç??é«?IGF-1è¡??????è¿?LH?ºæ????µæ³¡??ç»???å¢???ï¼?导è?´é??æ¿?ç´?è¿?å¤????µæ³¡è¿??©é????(??)??Hasegawa?¨è?°å?ç´?å¢?????Troglitazoneæ²»ç??PCOSï¼???½¿?°å?ç´?æ°´å¹³??ä½?ï¼?LH????æ¿?ç´?æ°´å¹³?¸å???ä½?ä¹?????è¿?ä¸?è§??¹ã???°å?ç´???é«?对è???SHBG??代谢????è¦?ä½??????½¿????SHBG??????å°?ï¼?游ç??¾é????é«???æ­¤å?ï¼??°å?ç´???ä½?ä¸?æ°¨é?¸ç£·?¸å???????¶è?°å?ç´???ä½?æ´»æ?§ï?ä¿?è¿?P450C17A??17ï¼?20-?¾è??¶æ´»?§ã??è¿?å¹´å?ä½?äº????²ä?11pl5.5???°å?ç´??ºå????5'-ç«??????°ä¸²????å¤?顺å?(VNTR)????究å???°ï??°å?ç´??ºå????VNTR??COS??ä¸?ä¸?¸»è¦?????ä½????¹å???????µæ??COS)??说æ???°å?ç´?VNTRå¤????§æ??COS????ä¼?å­þ@??ç´??? 6ï¼??¥è?? PCOSä¼´è?¥è????(BMI¡Ý25)??20%ï½?60%??ä½?????å¸?ä¸????????°ç?¥è?????ç»???±»?ºé??æ¿?ç´?????è¦?代谢?ºæ??ï¼??????ç»?ä¸????³é????¶å?å¤??¨é??æ¿?ç´?è½???¸ºE1??E2????究è?å®?ï¼????????½¬??¸ºE1????ä¸??????ç»??»é???¸å?³ï?é«???æ¿?ç´?è¡?????HBGä¸???ï¼?游ç?E2å¢???????æ¿?ç´?使è??????????¿ã??å¢?æ®???ä¸?????????æ³?????½é????ä¸??????¥è??ä½???ï¼???æ¿?ç´???é«?表ç?°ä¸ºä¸?èº??¥è??(?³ç?·æ?§å???¥è??)ï¼?????æ¿?ç´?å¢?å¤???为ä?èº??¥è??(?³å¥³?§å???¥è??)??ä½???å¢???常伴è¡??°å?ç´???é«???SHBG??IGFBPä¸???ï¼?ä»???使游离æ?§æ?ç´???IGF-1å¢?å¤???è¿?ç±»æ?£è??常伴??ç³?????å¼?常æ??2??ç³?å°¿ç????????è¿??¥ï?Rouruç­????ºè?¥è??-?þ>?-NPYè½´å???½æ???¨å??PCOS?£è??ä¸?ä¸???-??ä½?-LHè¿?åºþ@??æ³???????ï¼??³è?¥è??å¦?女ç???þ>???æ³?å¢?å¤?ï¼????????¶ä?ä¸???NPYmRNA表达??NPY????æ³?ï¼?解é??PYå¯?H?????¶ï?ä¿?ä½?H大é?????¾ã?? 7ï¼?é«?æ³?ä¹³ç?è¡??? é«?æ³?ä¹³ç?è¡???ä¸?PCOS???³ç³»å°?å¾?è¿?ä¸?æ­¥ç??究ã??PCOSé«?æ³?ä¹³ç?è¡???????????ä¸?0%ï½?15%ï¼?ä½?ç¡??ä¸?COS????PRL?½è½»åºþ=??ä¸?º¦??é«?ï¼??´é?æ°´å¹³??PRLå¤?ä¸???ä½?PRL?¤æ???³ã??å¼?èµ·é?PRL???ºå?¶å?ä¸?æ¸?æ¥??????½æ?????PRL??é«?ä¸?è¡??????å¤????³ã???¡ä?ä¸???å¤?å·´è?ºç?¸å?ä¸?足ï??¨å?å·´è?ºæ??¨å??(å¦?溴é??äº?æ²»ç??PCOS?????µæ??å¤?æ¯??????·å???????é«?PRLè¡??????µå·¢å¯¹å?æº??§ä??§è?ºæ?ç´?????åº??? 8ï¼?PCOSä¸??µå·¢??º«??? ??究å???°ï???äº?PCOSä¸??µå·¢??º«???????³ã??PCOS?£è???µæ³¡ä¸???æ·?å·´ç???浸润ï¼?并å??¨æ???µå·¢ç»?????ä½?ï¼?ä½?Rojanskyç­?å¯?1ä¾?PCOS?£è??????究æ?¾ç¤ºï¼????µå·¢??ä½?ä¸?PCOS???¸å?³ã??Luborskyç­??¨é?¶å??????æ£?æµ?24ä¾?PCOS?????µå·¢??ä½?ï¼?25%PCOS?£è??为é?³æ?§ï?ç»?ç»???å¦?女ç?ä¸??²é?å¦?女ç????³æ?§ç??????¸º22%??19%ï¼?3ç»??³æ?§ç????å·??????æ­¤ï??³ä?PCOS???þ???µå·¢??º«???????³å???ä¸??´ç?论ã???????µå·¢????ï¼??¸å????PCOS?£è??????侧å?µå·¢å¯¹ç§°?§å?大ï?ä½?ç§???¾¾æ­£å¸¸??2ï½?4??ï¼?表é?¢ç?±è¤¶æ¶?失ï?å¹³æ?ï¼????°ç?½è?²ï?å¯????管ï??????¥å??ï¼?????ä¸???å¤???大å?ä¸?ç­????µæ³¡ï¼???大ç?´å???¾¾1.5cmï¼???å£???ï¼???泡å?¨å?´ç???µæ³¡??ç»???å¢???ä¼´é?ç´???ï¼?????å¢????????¿æ??ä¸????µç??ç»???ï¼???????åºþ??è¡?LHæ°´å¹³???·æ?§å??ç¨?åºþ@??æ­£ç?¸å?³ã??

  • ???½ç?¾ç??ï¼??µå·¢?§ä?å­??µå·¢çº¤ç»´ç»?ç»??¥æ??¿ç??/a>?????§å?µå·¢ç»????¥æ?§è??µç??µå·¢???°å?ç´??µæ??ä¸?代谢综å??å¾?

  • 常è?æ£??¥ï?

  • å°±è?ç§?室ï?å¦?ç§???????æ³?

???¨è????